Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

• Main Authors: Andrew S Bell (Author), James E Mills (Author), Gareth P Williams (Author), James A Brannigan (Author), Anthony J Wilkinson (Author), Tanya Parkinson (Author), Robin J Leatherbarrow (Author), Edward W Tate (Author), Anthony A Holder (Author), Deborah F Smith (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a diverse subset of the Pfizer corporate collection agai...