Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Overview of the Pathophysiology of Atopic Dermatitis
Abstract.: It has been recognized that atopic dermatitis (AD) involves allergen-driven Th2 cell polarization. In patients with AD, cytokines induce allergic inflammatory responses and subsequently enhance IgE production. Recent reports revealed that a reduced barrier function as well as altered immu...
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Elsevier,
2009-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_f9d619b2ac2d4e7eab9cb6faaff1be81 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Tadashi Terui |e author |
| 245 | 0 | 0 | |a Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Overview of the Pathophysiology of Atopic Dermatitis |
| 260 | |b Elsevier, |c 2009-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.09R02FM | ||
| 520 | |a Abstract.: It has been recognized that atopic dermatitis (AD) involves allergen-driven Th2 cell polarization. In patients with AD, cytokines induce allergic inflammatory responses and subsequently enhance IgE production. Recent reports revealed that a reduced barrier function as well as altered immunity are fundamental to the development of AD because barrier disruption due to aberrant filaggrin expression is a pathological factor. However, although recent studies have improved our understanding of the pathogenesis of AD, the overall pathophysiology remains elusive. I herein discuss it based on the natural history of AD. Keywords:: atopic dermatitis, nonatopic dermatitis, barrier dysfunction, filaggrin, IgE autoantibody, allergic inflammation | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 110, Iss 3, Pp 232-236 (2009) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319311697 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f9d619b2ac2d4e7eab9cb6faaff1be81 |z Connect to this object online. |