Associations Between Serum 25-Hydroxyvitamin D Levels and Thyroid Function Parameters in Previously Healthy Children Aged 6 to 24 Months

• Main Authors: Guo Y (Author), Wu CY (Author), Deng YH (Author), Wu JL (Author)
• Format: Book
• Published: Dove Medical Press, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Yong Guo, Chun-Yan Wu, Yu-Hong Deng, Jie-Ling Wu Department of Children&rsquo;s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 511400, People&rsquo;s Republic of ChinaCorrespondence: Jie-Ling WuDepartment of Children&rsquo;s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 511400, People&rsquo;s Republic of ChinaTel [phone]Email [e-mail]: Vitamin D deficiency has been linked to overt thyroid diseases. Data on the effects of vitamin D status on thyroid function in children are less examined. The goal of the present study was to explore the association between serum 25-hydroxyvitamin D [25(OH)D] levels and thyroid function parameters in early childhood.Patients and Methods: This was a cross-sectional study involving record-linkage of children&rsquo;s data of routine health check-ups for promoting early childhood development at Guangdong Women and Children&rsquo;s Hospital; 2869 children aged 6&ndash; 24 months were included from January 2015 to May 2017. Serum 25(OH)D, thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured using the electrochemiluminescence immunoassay.Results: The study population had a mean serum 25(OH)D level of 79.7 &plusmn; 28.1 nmol/L and 12.5% vitamin D deficiency and 36.0% insufficiency rates. The rates of thyroid dysfunctions detected were 2.9% hypothyroidism, 4.2% subclinical hypothyroidism, 0.9% hyperthyroidism, and 1.7% subclinical hyperthyroidism among the previously healthy children aged 6 to 24 months. Serum 25(OH)D levels had no significant correlation with TSH (r = 0.022, P = 0.236), FT3 (r = 0.014, P = 0.440) and FT4 (r = &minus; 0.059, P = 0.056) levels. No significant difference in the levels of thyroid hormones was found between the different quartiles of 25(OH)D level. Vitamin D deficiency [25(OH)D < 50 nmol/L] was associated with hypothyroidism (adjusted odds ratio = 2.16, 95% confidence interval: 1.18&ndash; 3.94) but not with subclinical hypothyroidism, hyperthyroidism, and subclinical hyperthyroidism.Conclusion: Vitamin D deficiency is slightly associated with hypothyroidism. No associations were found between serum 25(OH)D levels and thyroid-related measures (TSH, FT3, and FT4) in previously healthy children aged 6&ndash; 24 months.Keywords: thyroid stimulating hormone, free triiodothyronine, free thyroxine

Item Description

1179-1594