Prevalence of autoimmune thyroiditis in patients with type 1 diabetes: a long-term follow-up study

• Main Authors: Gum Bit Hwang (Author), Jong Seo Yoon (Author), Kyu Jung Park (Author), Hae Sang Lee (Author), Jin Soon Hwang (Author)
• Format: Book
• Published: Korean Society of Pediatric Endocrinology, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Purpose Type 1 diabetes mellitus (DM) is associated with autoimmune diseases such as thyroiditis. Therefore, we aimed to investigate the prevalence of autoimmune thyroiditis in patients with type 1 DM. Methods A total of 102 patients who were diagnosed and followed up (mean age, 8.1±4.0 years) in Ajou University Hospital were enrolled in this study. All the patients were evaluated for beta cell autoimmunity, including insulin autoantibody, glutamic acid decarboxylase antibodies (GADA), and islet cell antibody. Moreover, autoantibodies to thyroid peroxidase and thyroglobulin were assessed at initial diagnosis and annually thereafter. Results The mean patient age (49 men and 53 women) was 19.2±4.8 years. The prevalence of at least one thyroid antibody was 30.4%. Patients with thyroid anti­bodies had a significantly higher frequency of GADA at the time of the diagnosis. Autoimmune thyroiditis was more prevalent in the older age group. GADA was a significant risk factor for development of thyroid autoantibodies after diagnosis of type 1 DM (odds ratio, 4.45; 95% confidence interval, 1.399-14.153). Conclusions In patients with type 1 DM, the prevalence of autoimmune thyroiditis was higher than in the general population. Moreover, GADA positivity at diagnosis was associated with thyroid autoimmunity.

Item Description

2287-1012
2287-1292
10.6065/apem.2018.23.1.33