Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes

• Main Authors: Shangyu Hong (Author), Wei Song (Author), Peter-James H. Zushin (Author), Bingyang Liu (Author), Mark P. Jedrychowski (Author), Amir I. Mina (Author), Zhaoming Deng (Author), Dimitrije Cabarkapa (Author), Jessica A. Hall (Author), Colin J. Palmer (Author), Hassan Aliakbarian (Author), John Szpyt (Author), Steven P. Gygi (Author), Ali Tavakkoli (Author), Lydia Lynch (Author), Norbert Perrimon (Author), Alexander S. Banks (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The inappropriate release of free fatty acids from obese adipose tissue stores has detrimental effects on metabolism, but key molecular mechanisms controlling FFA release from adipocytes remain undefined. Although obesity promotes systemic inflammation, we find activation of the inflammat...