Antioxidant and Anti-Inflammaging Ability of Prune (<i>Prunus Spinosa</i> L.) Extract Result in Improved Wound Healing Efficacy
<i>Prunus spinosa L.</i> fruit (PSF) ethanol extract, showing a peculiar content of biologically active molecules (polyphenols), was investigated for its wound healing capacity, a typical feature that declines during aging and is negatively affected by the persistence of inflammation and...
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MDPI AG,
2021-03-01T00:00:00Z.
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| 001 | doaj_fadd2e00c95548c7a3d65a0f8b3855e6 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Sofia Coppari |e author |
| 700 | 1 | 0 | |a Mariastella Colomba |e author |
| 700 | 1 | 0 | |a Daniele Fraternale |e author |
| 700 | 1 | 0 | |a Vanessa Brinkmann |e author |
| 700 | 1 | 0 | |a Margherita Romeo |e author |
| 700 | 1 | 0 | |a Marco Bruno Luigi Rocchi |e author |
| 700 | 1 | 0 | |a Barbara Di Giacomo |e author |
| 700 | 1 | 0 | |a Michele Mari |e author |
| 700 | 1 | 0 | |a Loretta Guidi |e author |
| 700 | 1 | 0 | |a Seeram Ramakrishna |e author |
| 700 | 1 | 0 | |a Natascia Ventura |e author |
| 700 | 1 | 0 | |a Maria Cristina Albertini |e author |
| 245 | 0 | 0 | |a Antioxidant and Anti-Inflammaging Ability of Prune (<i>Prunus Spinosa</i> L.) Extract Result in Improved Wound Healing Efficacy |
| 260 | |b MDPI AG, |c 2021-03-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox10030374 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a <i>Prunus spinosa L.</i> fruit (PSF) ethanol extract, showing a peculiar content of biologically active molecules (polyphenols), was investigated for its wound healing capacity, a typical feature that declines during aging and is negatively affected by the persistence of inflammation and oxidative stress. To this aim, first, PSF anti-inflammatory properties were tested on young and senescent LPS-treated human umbilical vein endothelial cells (HUVECs). As a result, PSF treatment increased miR-146a and decreased IRAK-1 and IL-6 expression levels. In addition, the PSF antioxidant effect was validated in vitro with DPPH assay and confirmed by in vivo treatments in <i>C. elegans</i>. Our findings showed beneficial effects on worms' lifespan and healthspan with positive outcomes on longevity markers (i.e., miR-124 upregulation and miR-39 downregulation) as well. The PSF effect on wound healing was tested using the same cells and experimental conditions employed to investigate PSF antioxidant and anti-inflammaging ability. PSF treatment resulted in a significant improvement of wound healing closure (ca. 70%), through cell migration, both in young and older cells, associated to a downregulation of inflammation markers. In conclusion, PSF extract antioxidant and anti-inflammaging abilities result in improved wound healing capacity, thus suggesting that PSF might be helpful to improve the quality of life for its beneficial health effects. | ||
| 546 | |a EN | ||
| 690 | |a polyphenols | ||
| 690 | |a MicroRNA | ||
| 690 | |a HUVEC | ||
| 690 | |a lifespan | ||
| 690 | |a <i>C. elegans</i> | ||
| 690 | |a tissue regeneration | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 10, Iss 3, p 374 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/10/3/374 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fadd2e00c95548c7a3d65a0f8b3855e6 |z Connect to this object online. |