Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres

• Main Authors: Shaomin Wang (Author), Liang Wang (Author), Qian Bu (Author), Qian Wei (Author), Linhong Jiang (Author), Yanping Dai (Author), Ni Zhang (Author), Weihong Kuang (Author), Yinglan Zhao (Author), Xiaobo Cen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Methamphetamine (METH) abuse by pregnant drug addicts causes toxic effects on fetal neurodevelopment; however, the mechanism underlying such effect of METH is poorly understood.Methods: In the present study, we applied three-dimensional (3D) neurospheres derived from the embryonic rat...