Dominant Negative c-Jun Inhibits Platelet-Derived Growth Factor- Directed Migration by Vascular Smooth Muscle Cells
The mitogen≫activated protein (MAP) kinase pathways has been shown to be necessary for mitogen-stimulated proliferation, but its role in cell migration has not been fully understood. In this study, we investigated the possible contribution of signaling pathways through c-Jun in platelet-derived grow...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2003-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_fb733cc726f94ac1a02f74f5b38c5f59 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Takeshi Ioroi |e author |
| 700 | 1 | 0 | |a Motohiro Yamamori |e author |
| 700 | 1 | 0 | |a Keiko Yagi |e author |
| 700 | 1 | 0 | |a Midori Hirai |e author |
| 700 | 1 | 0 | |a Yumei Zhan |e author |
| 700 | 1 | 0 | |a Shokei Kim |e author |
| 700 | 1 | 0 | |a Hiroshi Iwao |e author |
| 245 | 0 | 0 | |a Dominant Negative c-Jun Inhibits Platelet-Derived Growth Factor- Directed Migration by Vascular Smooth Muscle Cells |
| 260 | |b Elsevier, |c 2003-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/S1347-8613(19)32754-9 | ||
| 520 | |a The mitogen≫activated protein (MAP) kinase pathways has been shown to be necessary for mitogen-stimulated proliferation, but its role in cell migration has not been fully understood. In this study, we investigated the possible contribution of signaling pathways through c-Jun in platelet-derived growth factor (PDGF)-BB directed cell migration in rat aortic vascular smooth muscle cells (VSMCs) infected with a recombinant adenovirus containing the dominant-negative c-Jun (Ad-DN-c-Jun). DN-c-Jun protein was expressed dose-dependently in VSMCs infected with Ad-DN-c-Jun. Expression of DN-c-Jun significantly inhibited VSMC migration induced by PDGF-BB. Our results provide the first evidence that signaling pathways through c-Jun participates in cell migration induced by PDGF-BB in addition to other MAP kinase pathways in VSMCs. | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 91, Iss 2, Pp 145-148 (2003) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319327549 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fb733cc726f94ac1a02f74f5b38c5f59 |z Connect to this object online. |