Lipid droplets are formed in 2-cell-like cells
Embryonic stem (ES) cells, derived from the inner cell mass of a blastocyst, are believed to pluripotent cells and give rise to embryonic, but not extraembryonic, tissues. In mice, totipotent 2-cell stage embryo-like (2-cell-like) cells, which are identified by reactivation of murine endogenous retr...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
The Society for Reproduction and Development,
2021-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Embryonic stem (ES) cells, derived from the inner cell mass of a blastocyst, are believed to pluripotent cells and give rise to embryonic, but not extraembryonic, tissues. In mice, totipotent 2-cell stage embryo-like (2-cell-like) cells, which are identified by reactivation of murine endogenous retrovirus with leucin transfer RNA primer (MuERV-L), arise at a very few frequencies in ES cell cultures. Here, we found that a lipid droplet forms during the transition from ES cells to 2-cell-like cells, and we propose that 2-cell-like cells utilize a unique energy storage and production pathway. |
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| Item Description: | 0916-8818 1348-4400 10.1262/jrd.2021-003 |