Relationship between the early repolarization pattern and a history of suicide attempts among drug‐free psychiatric patients

• Main Authors: Hiroshi Kameyama (Author), Kenichi Sugimoto (Author), Fumitoshi Kodaka (Author), Kyoko Ito (Author), Kazutaka Nukariya (Author), Tomohiro Kato (Author), Masahiro Shigeta (Author)
• Format: Book
• Published: Wiley, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2574-173X; 10.1002/npr2.12254
• Keywords: early repolarization pattern; electrocardiogram; mental health; psychiatric disorders; suicide; Therapeutics. Pharmacology; RM1-950; Neurosciences. Biological psychiatry. Neuropsychiatry; RC321-571
• Source: Neuropsychopharmacology Reports, Vol 42, Iss 3, Pp 256-262 (2022)

Abstract Aim Suicide attempts are an important severe psychiatric symptom and a clear outcome for mental disorders. Although the relationship between the early repolarization pattern in electrocardiogram and psychiatric disorders has recently been reported, these reports have not been able to exclude the influence of psychiatric drugs. This study aimed to investigate the relationship between the early repolarization pattern and a history of suicide attempts among patients not receiving psychiatric medication. Methods A total of 71 patients with a history of suicide attempts were investigated, 38 of whom were analyzed for this study. We compared the frequency of the early repolarization pattern between a suicide attempt group and a control group. Then, we investigated the association between the early repolarization pattern and the suicide attempt group by logistic regression analysis, including electrocardiographic findings associated with psychiatric disorders. Results The findings indicated that the frequency of the early repolarization pattern was significantly higher in the suicide attempt group (n = 20; 52.6%) than in the control group (n = 4; 10.5%) (P < 0.001), and the results of the logistic regression analysis indicated that the early repolarization pattern was associated with suicide attempts. Conclusions These findings suggest that the early repolarization pattern is associated with a history of suicide attempts.