Exploring the Link between <i>Helicobacter pylori</i>, Gastric Microbiota and Gastric Cancer
Gastric cancer (GC) still represents one of the leading causes of cancer-related mortality and is a major public health issue worldwide. Understanding the etiopathogenetic mechanisms behind GC development holds immense potential to revolutionize patients' treatment and prognosis. Within the com...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2024-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Gastric cancer (GC) still represents one of the leading causes of cancer-related mortality and is a major public health issue worldwide. Understanding the etiopathogenetic mechanisms behind GC development holds immense potential to revolutionize patients' treatment and prognosis. Within the complex web of genetic predispositions and environmental factors, the connection between <i>Helicobacter pylori</i> (<i>H. pylori</i>) and gastric microbiota emerges as a focus of intense research investigation. According to the most recent hypotheses, <i>H. pylori</i> triggers inflammatory responses and molecular alterations in gastric mucosa, while non-<i>Helicobacter</i> microbiota modulates disease progression. In this review, we analyze the current state of the literature on the relationship between <i>H. pylori</i> and non-<i>Helicobacter</i> gastric microbiota in gastric carcinogenesis, highlighting the mechanisms by which microecological dysbiosis can contribute to the malignant transformation of the mucosa. |
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| Item Description: | 10.3390/antibiotics13060484 2079-6382 |