Enhanced Bioavailability of AC1497, a Novel Anticancer Drug Candidate, via a Self-Nanoemulsifying Drug Delivery System

• Main Authors: Kshitis Chandra Baral (Author), Jae-Geun Song (Author), Sang Hoon Lee (Author), Rajiv Bajracharya (Author), Godesi Sreenivasulu (Author), Minkyoung Kim (Author), Kyeong Lee (Author), Hyo-Kyung Han (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AC1497 is an effective dual inhibitor of malate dehydrogenase 1 and 2 targeting cancer metabolism. However, its poor aqueous solubility results in low bioavailability, limiting its clinical development. This study was conducted to develop an effective self-nanoemulsifying drug delivery system (SNEDD...