Cover Image

No drug-drug interactions between selective prolyl‐tRNA synthetase inhibitor, bersiporocin, and pirfenidone or nintedanib in healthy participants

Abstract Bersiporocin, a potent and selective prolyl‐tRNA synthetase inhibitor, is expected to show a synergistic effect with pirfenidone or nintedanib in patients with idiopathic pulmonary fibrosis. To validate the combination therapy of bersiporocin with pirfenidone or nintedanib, a randomized, op...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wonsuk Shin (Author), Min Young Park (Author), Jongwoo Kim (Author), Jihyeon Kim (Author), Jun Hee Nam (Author), Jongwon Choi (Author), A‐Young Yang (Author), Hyounggyoon Yoo (Author), Yil‐Seob Lee (Author), Anhye Kim (Author)
Format:	Book
Published:	Wiley, 2024-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Safety, tolerability, pharmacokinetic/pharmacodynamic characteristics of bersiporocin, a novel prolyl‐tRNA synthetase inhibitor, in healthy subjects
by: Min Young Park, et al.
Published: (2023)

Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis
by: Dae-Geun Song, et al.
Published: (2018)

Drug-Drug Interactions between Tamsulosin and Mirabegron in Healthy Individuals Do Not Affect Pharmacokinetics and Hemodynamic Parameters Significantly
by: Wonsuk Shin, et al.
Published: (2023)

Pirfenidone and Nintedanib in Pulmonary Fibrosis: Lights and Shadows
by: Maria Chianese, et al.
Published: (2024)

Efficacy and safety of combination therapy with pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis
by: Jin-Young Huh, et al.
Published: (2023)

Evaluation of Pirfenidone and Nintedanib in a Human Lung Model of Fibrogenesis
by: KM Roach, et al.
Published: (2021)

In Vitro Evaluation of Drug-Drug Interaction Potential of Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor
by: Afshin Shafiee, et al.
Published: (2024)

The regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease
by: Yulin Zou, et al.
Published: (2021)

Comparison of the safety profiles for pirfenidone and nintedanib: a disproportionality analysis of the US food and drug administration adverse event reporting system
by: Xiangyu Sun, et al.
Published: (2024)

Assessing the Clinical Efficacy of Therapeutic Drug Monitoring for Risperidone and Paliperidone in Patients with Schizophrenia: Insights from a Clinical Data Warehouse
by: Wonsuk Shin, et al.
Published: (2024)

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.
by: Cho Yeow Koh, et al.
Published: (2014)

A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase
by: Marissa A. Holmbeck, et al.
Published: (2015)

Pharmacological Interactions of Nintedanib and Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis in Times of COVID-19 Pandemic
by: José M. Serra López-Matencio, et al.
Published: (2021)

Mutation in methionyl-tRNA synthetase 1 causing pulmonary alveolar proteinosis
by: Manoj Madhusudan, et al.
Published: (2023)

Leucyl-tRNA Synthetase Inhibitor, D-Norvaline, in Combination with Oxacillin, Is Effective against Methicillin-Resistant <i>Staphylococcus aureus</i>
by: Hong-Ju Lee, et al.
Published: (2022)

South-West of England's Experience of the Safety and Tolerability Pirfenidone and Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)
by: Shaney L. Barratt, et al.
Published: (2018)

The role of nintedanib and pirfenidone in the treatment of idiopathic pulmonary fibrosis and review of recent clinical trials of IPF therapy
by: Michał Żuber, et al.
Published: (2024)

A Comparative Pharmacokinetic Study of Fexuprazan 10 mg: Demonstrating Bioequivalence with the Reference Formulation and Evaluating Steady State
by: Wonsuk Shin, et al.
Published: (2023)

Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases
by: Manesh Nautiyal, et al.
Published: (2019)

Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis.
by: Arvind Sharma, et al.
Published: (2016)

Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens.
by: Paul Kelly, et al.
Published: (2020)

Phenylalanyl-tRNA synthetase deficiency caused by biallelic variants in FARSA gene and literature review
by: Ruolan Guo, et al.
Published: (2023)

Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells.
by: Manuel Castro de Moura, et al.
Published: (2011)

Effects of Pirfenidone and Nintedanib on Markers of Systemic Oxidative Stress and Inflammation in Patients with Idiopathic Pulmonary Fibrosis: A Preliminary Report
by: Alessandro G. Fois, et al.
Published: (2020)

Correction: Entamoeba lysyl-tRNA Synthetase Contains a Cytokine-Like Domain with Chemokine Activity towards Human Endothelial Cells.
by: Manuel Castro de Moura, et al.
Published: (2024)

Identifying potential natural inhibitors of Brucella melitensis Methionyl-tRNA synthetase through an in-silico approach.
by: Adekunle Babajide Rowaiye, et al.
Published: (2022)

Glycyl tRNA Synthetase (GARS) Gene Variant Causes Distal Hereditary Motor Neuropathy V
by: Peter Chung, et al.
Published: (2018)

Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors
by: Anca Stana, et al.
Published: (2019)

Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target.
by: Sanya Chadha, et al.
Published: (2018)

An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor
by: Eva Habjan, et al.
Published: (2021)

Risk of potential hepatotoxicity from pirfenidone or nintedanib in patients with idiopathic pulmonary fibrosis: results of a retrospective analysis of a large insurance database in Taiwan
by: Kuang-Ming Liao, et al.
Published: (2024)

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening
by: Diego Benítez, et al.
Published: (2022)

Clinical, radiological, and serological assessment of the efficacy and safety of nintedanib compared to pirfenidone in a sample of Iraqi patients with idiopathic pulmonary fibrosis: A retrospective cohort study
by: Walaa Abdul Jabbar Al-Sarraf, et al.
Published: (2024)

Pirfenidone-induced dose-dependent phototoxicity - a distinct drug reaction
by: P Arunprasath, et al.
Published: (2020)

Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis
by: Donghao Gan, et al.
Published: (2021)

Exploring <i>Proteus mirabilis</i> Methionine tRNA Synthetase Active Site: Homology Model Construction, Molecular Dynamics, Pharmacophore and Docking Validation
by: Samar S. Elbaramawi, et al.
Published: (2023)

Fatty acid synthetase expression in triple-negative breast cancer
by: Jin Hee Park, et al.
Published: (2022)

Epetraborole, a leucyl-tRNA synthetase inhibitor, demonstrates murine efficacy, enhancing the in vivo activity of ceftazidime against Burkholderia pseudomallei, the causative agent of melioidosis.
by: Jason E Cummings, et al.
Published: (2023)

Biphasic Effect of Pirfenidone on Angiogenesis
by: Donghao Gan, et al.
Published: (2022)

Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
by: Yue Zhang, et al.
Published: (2020)