Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study
Ranju Pokharel,1 Sudha Agrawal,1 Prajwal Pandey,1 Madhab Lamsal2 1Department of Dermatology and Venereology, B.P Koirala Institute of Health Sciences, Dharan, Nepal; 2Department of Biochemistry, B.P Koirala Institute of Health Sciences, Dharan, NepalCorrespondence: Ranju Pokharel, Junior Resident, D...
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Dove Medical Press,
2022-09-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Pokharel R |e author |
| 700 | 1 | 0 | |a Agrawal S |e author |
| 700 | 1 | 0 | |a Pandey P |e author |
| 700 | 1 | 0 | |a Lamsal M |e author |
| 245 | 0 | 0 | |a Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study |
| 260 | |b Dove Medical Press, |c 2022-09-01T00:00:00Z. | ||
| 500 | |a 2230-326X | ||
| 520 | |a Ranju Pokharel,1 Sudha Agrawal,1 Prajwal Pandey,1 Madhab Lamsal2 1Department of Dermatology and Venereology, B.P Koirala Institute of Health Sciences, Dharan, Nepal; 2Department of Biochemistry, B.P Koirala Institute of Health Sciences, Dharan, NepalCorrespondence: Ranju Pokharel, Junior Resident, Department of Dermatology and Venereology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal, Tel +9779860660852, Email ranjupokharel.rp@gmail.comBackground: Chronic plaque psoriasis is a chronic inflammatory skin disorder. Vitamin D has been shown to have effects on keratinocyte differentiation as well as immune regulation in the skin.Objective: The main objective of this study was to assess the 25hydroxyvitamin D [25 (OH) D] level in patients with psoriasis in comparison with healthy control subjects.Materials and Methods: This case-control study included 180 persons (120 cases and 60 age- and sex-matched control subjects) from outpatient department of BPKIHS, a tertiary care hospital in eastern Nepal. Severity of psoriatic skin lesions was assessed using psoriasis area severity index (PASI) scoring. Serum vitamin D level was assessed by chemiluminescent immunoassay.Results: The mean serum 25(OH) D levels in psoriatic patients and controls were 19.57 ± 6.85 ng/mL and 23.63 ± 6.40 ng/mL, respectively. The difference was statistically significant even after adjusting for confounding factors in a multivariate analysis (aOR 2.929, 95% CI 1.376- 6.230). Low serum 25(OH) D levels were negatively associated with the severity of disease (r= − 0.628, P= 0.01).Conclusion: Serum 25(OH) D levels are significantly lower in psoriatic patients than in healthy control subjects. Deficiency of serum 25(OH) D was associated with severity of disease with an inverse relationship with PASI score.Keywords: psoriasis, psoriasis area severity index, 25hydroxyvitamin vitamin D | ||
| 546 | |a EN | ||
| 690 | |a psoriasis | ||
| 690 | |a psoriasis area severity index | ||
| 690 | |a 25hydroxyvitamin vitamin d | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Psoriasis: Targets and Therapy, Vol Volume 12, Pp 251-258 (2022) | |
| 787 | 0 | |n https://www.dovepress.com/assessment-of-vitamin-d-level-in-patients-with-psoriasis-and-its-corre-peer-reviewed-fulltext-article-PTT | |
| 787 | 0 | |n https://doaj.org/toc/2230-326X | |
| 856 | 4 | 1 | |u https://doaj.org/article/fca08d40963e42dea801f4b9e4da7ee6 |z Connect to this object online. |