Cover Image

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

We investigated a panel of 14 compounds belonging to the monothiocarbamate (MTC) and dithiocarbamate (DTC) series against the β-carbonic anhydrase 3 (β-CA3) of Mycobacterium tuberculosis (Mtb). We also evaluated all compounds for toxicity using 1-5-day post fertilisation zebrafish embryos. 11 out of...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ashok Aspatwar (Author), Milka Hammaren (Author), Mataleena Parikka (Author), Seppo Parkkila (Author), Fabrizio Carta (Author), Murat Bozdag (Author), Daniela Vullo (Author), Claudiu T. Supuran (Author)
Format:	Book
Published:	Taylor & Francis Group, 2020-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis
by: Ashok Aspatwar, et al.
Published: (2017)

A cheminformatics and network pharmacology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors
by: Ajay Manaithiya, et al.
Published: (2024)

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases
by: Ashok Aspatwar, et al.
Published: (2020)

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes
by: Ashok Aspatwar, et al.
Published: (2018)

Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae
by: Simone Giovannuzzi, et al.
Published: (2022)

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii
by: Silvia Bua, et al.
Published: (2018)

An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureus
by: Linda J. Urbanski, et al.
Published: (2021)

Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties
by: Kalyan K. Sethi, et al.
Published: (2021)

Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae
by: Daniela Vullo, et al.
Published: (2018)

Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols
by: Alessandro Bonardi, et al.
Published: (2022)

Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris
by: Ashok Aspatwar, et al.
Published: (2023)

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
by: Morteza Abdoli, et al.
Published: (2017)

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series
by: Ashok Aspatwar, et al.
Published: (2020)

Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase
by: Andrea Angeli, et al.
Published: (2022)

First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors
by: Chiara Testa, et al.
Published: (2022)

Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids
by: Andrea Angeli, et al.
Published: (2021)

Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase
by: Linda J. Urbanski, et al.
Published: (2020)

Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris
by: Ashok Aspatwar, et al.
Published: (2022)

Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni
by: Susanna Haapanen, et al.
Published: (2023)

Priming of innate antimycobacterial immunity by heat-killed Listeria monocytogenes induces sterilizing response in the adult zebrafish tuberculosis model
by: Hanna Luukinen, et al.
Published: (2018)

Carbonic Anhydrases and Metabolism
by: Supuran, Claudiu T.
Published: (2019)

Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides
by: Linda J. Urbański, et al.
Published: (2021)

Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action
by: Marco Bragagni, et al.
Published: (2017)

Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates
by: Alessio Nocentini, et al.
Published: (2017)

Carbonic anhydrase I, II, IV and IX inhibition with a series of 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives
by: Murat Bozdag, et al.
Published: (2017)

Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases
by: Mikhail Krasavin, et al.
Published: (2017)

Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish
by: Henna Myllymäki, et al.
Published: (2018)

Sulfonamide inhibition studies of two β-carbonic anhydrases from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2
by: Daniela Vullo, et al.
Published: (2018)

Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry
by: Marta Menicatti, et al.
Published: (2018)

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators
by: Suleyman Akocak, et al.
Published: (2017)

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities
by: Claudiu T. Supuran
Published: (2022)

Coumarin carbonic anhydrase inhibitors from natural sources
by: Claudiu T. Supuran
Published: (2020)

The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy
by: Elena Andreucci, et al.
Published: (2019)

Acipimox inhibits human carbonic anhydrases
by: Mattia Mori, et al.
Published: (2022)

Carbonic anhydrase inhibitory properties of some uracil derivatives
by: Emir Alper Türkoğlu, et al.
Published: (2017)

Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety
by: Hasan Küçükbay, et al.
Published: (2020)

Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens
by: Daniela Vullo, et al.
Published: (2018)

Bacterial carbonic anhydrases as drug targets: towards novel antibiotics ?
by: Claudiu T. Supuran
Published: (2011)

Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates
by: Simone Giovannuzzi, et al.
Published: (2023)

Inhibition of α-, β-, γ-, and δ-carbonic anhydrases from bacteria and diatoms with N'-aryl-N-hydroxy-ureas
by: Emanuela Berrino, et al.
Published: (2018)