Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach

• Main Authors: Eduardo Barbosa Coelho (Author), Diego Alberto Ciscato Cusinato (Author), João Paulo Ximenez (Author), Vera Lucia Lanchote (Author), Claudio José Struchiner (Author), Guilherme Suarez-Kurtz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plasma concentration data points (n = 2,640) from 16 healthy adults were used to develop and validate limited sampling strategies (LSS) for estimation of phenotypic metrics for CYP enzymes and the ABCB1 transporter, using a cocktail of subtherapeutic doses of the selective probes caffeine (CYP1A2),...