Synergetic HepG2 cells suppression efficacy of Tripterygium wilfordii and Scutellaria barbata through EGFR/PI3K/Akt pathway

• Main Authors: Susu Liu (Author), Yuan Liu (Author), Luanying He (Author), Fei He (Author), Na Wang (Author), Jinting Peng (Author), Changyuan Yu (Author), Shihui Wang (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Traditional Chinese medicines (TCMs) Tripterygium wilfordii Hook. f. (TW) and Scutellaria barbata D. Don (SB) are reported to have anticancer activity. However, the synergetic anti-liver cancer efficacy is still unknown. Herein, we demonstrated that the combination of TW and fermentation product of SB by yeast (TW+SB) could markedly improve the HepG2 cell suppression capacity as compared to individual TW or SB. Hence, synergetic mechanisms of TW+SB combination were further investigated by systems pharmacology, LC-MS, etc. The results showed that fermentation increases the concentration of active components of SB rather than those of TW, leading to the increase of HepG2 cell inhibition efficacy of SB. TW+SB combination effectively suppresses proliferation, migration, and invasion of liver cancer cells by inducing EGFR/PI3K/Akt signaling pathway mediated apoptosis. In conclusion, TW+SB combination showed outstanding synergetic anti-liver cancer effect, and it might offer a promising treatment option for cancer patients.

Item Description

2667-1425
10.1016/j.prmcm.2022.100130