Comparison of proinsulin to C-peptide ratio in children with and without type 1 diabetes and its relation to age
Purpose This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio. Methods Nineteen participants (n=9 with type 1 diabetes and n=10 with no diabetes) between 10 and 19 y...
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| Format: | Book |
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Korean Society of Pediatric Endocrinology,
2020-03-01T00:00:00Z.
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| Summary: | Purpose This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio. Methods Nineteen participants (n=9 with type 1 diabetes and n=10 with no diabetes) between 10 and 19 years of age were enrolled in a single-visit cross-sectional study and underwent blood collection after 10 hours fasting to measure proinsulin and C-peptide levels as well as other glycemic parameters. Results The median PI:C ratio was significantly different between type 1 diabetes and nondiabetes groups (6.24% vs. 1.46%, P<0.01). A significant negative correlation was seen between PI:C ratio and patient age after adjustment for duration of diabetes (r2 =0.61, P=0.02) in the type 1 diabetes group. Conclusions Even in this narrow age window, a higher degree of β-cell dysfunction indicated by a higher PI:C ratio was seen in younger children. |
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| Item Description: | 2287-1012 2287-1292 10.6065/apem.2020.25.1.38 |