<i>Daphne jejudoensis</i> Attenuates LPS-Induced Inflammation by Inhibiting TNF-α, IL-1β, IL-6, iNOS, and COX-2 Expression in Periodontal Ligament Cells

• Main Authors: Ji-Yeong Bae (Author), Dong-Seol Lee (Author), You Kyoung Cho (Author), Ji-Yeon Lee (Author), Joo-Hwang Park (Author), Sang Ho Lee (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/ph15040387; 1424-8247
• Keywords: <i>Daphne jejudoensis</i>; anti-inflammatory activity; Thymelaeaceae; periodontitis; lipopolysaccharide; Medicine; R; Pharmacy and materia medica; RS1-441
• Source: Pharmaceuticals, Vol 15, Iss 4, p 387 (2022)

Periodontitis is a common disease involving inflammation and tissue destruction in the periodontal region. Although uncontrolled long-term inflammation in the gingiva may lead to loss of the periodontal ligament, treatments or preventive solutions for periodontitis are scarce. The aim of this study is to find anti-inflammatory material from a natural source that can be used to treat or protect against periodontitis. <i>Daphne</i> species (Thymelaeaceae) are important and popular components of traditional Chinese medicine and are used as anti-inflammatory agents. <i>Daphne jejudoensis</i> is an endemic plant that grows on Jeju Island and was identified as a new species in 2013. In this study, for the first time, we investigated the anti-inflammatory effect of <i>D. jejudoensis</i> leaf extract (DJLE) on human periodontal ligament cells. The gene expression levels of pro-inflammatory cytokines (interleukin-1β and 6 and tumor necrosis factor-α) and inflammation-inducible enzymes (inducible nitric oxide synthase and cyclooxygenase-2) were reduced after DJLE treatment with/without lipopolysaccharide stimulation. The findings of this study indicate that <i>D. jejudoensis</i> possesses anti-inflammatory activities, suggesting that DJLE may be a potential preventive and therapeutic agent for periodontitis.