Molecular Recognition by Pillar[5]arenes: Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
The formation of inclusion complexes between alkylsulfonate guests and a cationic pillar[5]arene receptor in water was investigated by NMR and ITC techniques. The results show the formation of host-guest complexes stabilized by electrostatic interactions and hydrophobic effects with binding constant...
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| Формат: | Книга |
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MDPI AG,
2021-12-01T00:00:00Z.
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MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_fd86c185e3ac4a9ab81c7c67fbfe4c8f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Borja Gómez-González |e author |
| 700 | 1 | 0 | |a Luis García-Río |e author |
| 700 | 1 | 0 | |a Nuno Basílio |e author |
| 700 | 1 | 0 | |a Juan C. Mejuto |e author |
| 700 | 1 | 0 | |a Jesus Simal-Gandara |e author |
| 245 | 0 | 0 | |a Molecular Recognition by Pillar[5]arenes: Evidence for Simultaneous Electrostatic and Hydrophobic Interactions |
| 260 | |b MDPI AG, |c 2021-12-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics14010060 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a The formation of inclusion complexes between alkylsulfonate guests and a cationic pillar[5]arene receptor in water was investigated by NMR and ITC techniques. The results show the formation of host-guest complexes stabilized by electrostatic interactions and hydrophobic effects with binding constants of up to 10<sup>7</sup> M<sup>−1</sup> for the guest with higher hydrophobic character. Structurally, the alkyl chain of the guest is included in the hydrophobic aromatic cavity of the macrocycle while the sulfonate groups are held in the multicationic portal by ionic interactions. | ||
| 546 | |a EN | ||
| 690 | |a pillararene | ||
| 690 | |a host:guest | ||
| 690 | |a supramolecular | ||
| 690 | |a hydrophobic | ||
| 690 | |a ITC | ||
| 690 | |a NMR | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 14, Iss 1, p 60 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/14/1/60 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fd86c185e3ac4a9ab81c7c67fbfe4c8f |z Connect to this object online. |