SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.

• Main Authors: Adrian Leontovyč (Author), Lenka Ulrychová (Author), Anthony J O'Donoghue (Author), Jiří Vondrášek (Author), Lucie Marešová (Author), Martin Hubálek (Author), Pavla Fajtová (Author), Marta Chanová (Author), Zhenze Jiang (Author), Charles S Craik (Author), Conor R Caffrey (Author), Michael Mareš (Author), Jan Dvořák (Author), Martin Horn (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Serine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-1). These proteases are recognized as antigens dur...