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Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug

IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and compared in various species. Four metabolites of IMMH-010 were identified, and the major metabolite was the parent compound, YPD-29B, which was mainly c...

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Main Authors: Yuchen Wang (Author), Xiao Liu (Author), Xiaowen Zou (Author), Shuting Wang (Author), Lijun Luo (Author), Yuke Liu (Author), Kai Dong (Author), Xiaoqing Yao (Author), Yan Li (Author), Xiaoguang Chen (Author), Li Sheng (Author)
Format: Book
Published: MDPI AG, 2021-04-01T00:00:00Z.
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