Drug Nanocrystals in Oral Absorption: Factors That Influence Pharmacokinetics

• Glavni autori: Luiza de Oliveira Macedo (Autor), Jéssica Fagionato Masiero (Autor), Nádia Araci Bou-Chacra (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2024-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Despite the safety and convenience of oral administration, poorly water-soluble drugs compromise absorption and bioavailability. These drugs can exhibit low dissolution rates, variability between fed and fasted states, difficulty permeating the mucus layer, and P-glycoprotein efflux. Drug nanocrysta...