Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study

• Main Authors: Vivian Lindholm (Author), Sari Pitkänen (Author), Marika Schröder (Author), Sonja Hahtola (Author), Helka Sahi (Author), Heini Halme (Author), Kirsi Isoherranen (Author)
• Format: Book
• Published: Medical Journals Sweden, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Previous research presents pulsed dye laser-mediated photodynamic therapy as a promising alternative to conventional red-light photodynamic therapy. In this study, 60 patients with 2 or more actinic keratoses randomly received either of these treatments on each side of the head. A physician blinded to the treatment evaluated treatment response at 6 months for each lesion, as completely, partially or not healed. Significantly lower complete clearance rates (10.3% vs 44.9%) and lesion-specific complete clearance rates were found for pulsed dye laser-mediated photodynamic therapy (47.9%) vs conventional red-light photodynamic therapy (73.4%). Significantly lower pain scores were found for pulsed dye laser-mediated photodynamic therapy, with a mean numerical rating of 2.3, compared with 4.1 for conventional red-light photodynamic therapy. The study population had a mean of 7.9 lesions, and 78% of patients had been treat­ed previously for actinic keratoses on the treatment area. To conclude, in a population with severe sun dam­age, pulsed dye laser-mediated photodynamic therapy seems less effective than conventional red-light photo­dynamic therapy. Pulsed dye laser-mediated photodynamic therapy may still be a treatment option for patients who are not compliant with conventional red-light photodynamic therapy.

Item Description

0001-5555
1651-2057
10.2340/00015555-3754