Glycovaccine Design: Optimization of Model and Antitubercular Carrier Glycosylation via Disuccinimidyl Homobifunctional Linker

• Main Authors: Sara Tengattini (Author), Davide Rubes (Author), Massimo Serra (Author), Luciano Piubelli (Author), Loredano Pollegioni (Author), Enrica Calleri (Author), Teodora Bavaro (Author), Gabriella Massolini (Author), Marco Terreni (Author), Caterina Temporini (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Conjugation via disuccinimidyl homobifunctional linkers is reported in the literature as a convenient approach for the synthesis of glycoconjugate vaccines. However, the high tendency for hydrolysis of disuccinimidyl linkers hampers their extensive purification, which unavoidably results in side-rea...