Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch
Scalp psoriatic itch is a common, bothersome, yet understudied, condition with numerous associated treatment challenges. The aim of this study was to enhance our understanding of the pathophysiology of scalp psoriatic itch. Immunohistochemical analysis of known neuroimmune mediators of pruritus was...
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Medical Journals Sweden,
2023-03-01T00:00:00Z.
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| 100 | 1 | 0 | |a Leigh A. Nattkemper |e author |
| 700 | 1 | 0 | |a Zoe M. Lipman |e author |
| 700 | 1 | 0 | |a Giuseppe Ingrasci |e author |
| 700 | 1 | 0 | |a Claudia Maldonado |e author |
| 700 | 1 | 0 | |a Juan Carlos Garces |e author |
| 700 | 1 | 0 | |a Enrique Loayza |e author |
| 700 | 1 | 0 | |a Gil Yosipovitch |e author |
| 245 | 0 | 0 | |a Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch |
| 260 | |b Medical Journals Sweden, |c 2023-03-01T00:00:00Z. | ||
| 500 | |a 10.2340/actadv.v103.4463 | ||
| 500 | |a 0001-5555 | ||
| 500 | |a 1651-2057 | ||
| 520 | |a Scalp psoriatic itch is a common, bothersome, yet understudied, condition with numerous associated treatment challenges. The aim of this study was to enhance our understanding of the pathophysiology of scalp psoriatic itch. Immunohistochemical analysis of known neuroimmune mediators of pruritus was conducted using scalp biopsies from 27 Hispanic psoriatic patients. Patients were categorized into mild/moderate or severe itch groups according to their itch intensity rating of scalp itch. Protease activated receptor (PAR2), substance P, transient receptor potential (TRP)V3, TRPM8 and interleukin-23 expression all correlated significantly with itch intensity. The pathophysiology of scalp psoriasis is largely non-histaminergic, mediated by PAR2, interleukin-23, transient receptor potential channels, and substance P. | ||
| 546 | |a EN | ||
| 690 | |a psoriasis | ||
| 690 | |a pruritus | ||
| 690 | |a scalp psoriasis | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Dermato-Venereologica, Vol 103 (2023) | |
| 787 | 0 | |n https://medicaljournalssweden.se/actadv/article/view/4463 | |
| 787 | 0 | |n https://doaj.org/toc/0001-5555 | |
| 787 | 0 | |n https://doaj.org/toc/1651-2057 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fdfc0a2d0d72461b936ac95ec09fc0a7 |z Connect to this object online. |