In vitro antimicrobial evaluation of pyrazolone derivatives
In this investigation, unsubstituted pyrazolin-3(5)-ones (MePzO= 3-methyl-5-pyrazolone, PrPzO= 3-propyl-5-pyrazolone and PhPzO= 3-phenyl-5-pyrazolone) have been synthesized. The synthesized compounds were also screened for their antibacterial activity against some Gram-positive and Gram-negative bac...
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| Format: | Book |
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Bangladesh Pharmacological Society,
2015-02-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_fe87afd285ad48bbb2cb771b3a8266d5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Leile Rahimi Ahar |e author |
| 700 | 1 | 0 | |a Moayad Hossaini Sadr |e author |
| 700 | 1 | 0 | |a Karim Zare |e author |
| 700 | 1 | 0 | |a Samad Motameni Tabatabaei |e author |
| 245 | 0 | 0 | |a In vitro antimicrobial evaluation of pyrazolone derivatives |
| 260 | |b Bangladesh Pharmacological Society, |c 2015-02-01T00:00:00Z. | ||
| 500 | |a 10.3329/bjp.v10i1.21166 | ||
| 500 | |a 1991-0088 | ||
| 520 | |a In this investigation, unsubstituted pyrazolin-3(5)-ones (MePzO= 3-methyl-5-pyrazolone, PrPzO= 3-propyl-5-pyrazolone and PhPzO= 3-phenyl-5-pyrazolone) have been synthesized. The synthesized compounds were also screened for their antibacterial activity against some Gram-positive and Gram-negative bacteria using agar well diffusion method. The compounds with different concentrations were prepared and the activity was determined by measuring the diameter of the inhibition zone (in mm). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the compounds were determined against six bacteria. The antibacterial activities were influenced functional groups (methyl, propyl and phenyl). PhPzO exhibited the strongest activity (MIC, 0.625 mg/mL; MBC, 2.5 mg/mL) against Bacillus subtilis. | ||
| 546 | |a EN | ||
| 690 | |a Antimicrobial | ||
| 690 | |a Pyrazolone | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Bangladesh Journal of Pharmacology, Vol 10, Iss 1 (2015) | |
| 787 | 0 | |n https://www.banglajol.info/index.php/BJP/article/view/21166 | |
| 787 | 0 | |n https://doaj.org/toc/1991-0088 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fe87afd285ad48bbb2cb771b3a8266d5 |z Connect to this object online. |