Effects of aerobic training and black carbon particles exposure on gene expression of NF-κB and TNF-α of hippocampus brain tissue of male rats
Purpose: The purpose of this study was to investigate the effect of aerobic exercise and black carbon particleson gene expression of NF-κB and TNF-α in rats.Methods: Twenty-four male Wistar rats with an average body mass 279.29±26.97 g were randomly dividedinto 4 groups A: without exposure PM10 and...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Shahid Beheshti University,
2018-08-01T00:00:00Z.
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| Summary: | Purpose: The purpose of this study was to investigate the effect of aerobic exercise and black carbon particleson gene expression of NF-κB and TNF-α in rats.Methods: Twenty-four male Wistar rats with an average body mass 279.29±26.97 g were randomly dividedinto 4 groups A: without exposure PM10 and aerobic exercise, B: aerobic training, C: exposure to PM10carbon black (5 mg/m3; per rat), D: and aerobic exercise concomitantly with exposure to PM10 carbon black.Twenty-four hours after the last training session and exposure, the animals were sacrificed. Real timePcr technique was used. Two-way ANOVA and post hoc LSD was used to determine the significance ofdifferences between groups.Results: There was significant difference between groups A and B (P=0.001) and B and D (P=0.003) in theamount of TNF-α. Significant difference between A and B groups (P=0.008) in the amount of NF-κB wasobserved.Conclusions: four weeks of aerobic exercise and PM10 exposure lead to modify the inflammatory factors ofNF-κB and TNF-α. It seems that these changes lead to reducing the risk of neurodegenerative diseases. |
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| Item Description: | 2676-3710 2645-4041 10.48308/joeppa.2018.98919 |