Cover Image

Selectively Induced Apoptosis in Human Neutrophils in the Presence of Oxidative Phenoxazines, 2-Amino-4,4α-dihydryo-4α-7H-phenoxazine-3-one and 2-Aminophenoxazine-3-one, Preceded by Decrease of Intracellular pH, Depolarization of the Mitochondria, and Inhibition of Superoxide Generation

Abstract.: The present research investigated the effect of the oxidative phenoxazines, 2-amino-4,4α-dihydryo-4α-7H-phenoxazine-3-one (Phx-1) and 2-amino-phenoxazine-3-one (Phx-3) on apoptosis induction and apoptosis-related early events in human neutrophils. When Phx-1 or Phx-3 was administered to f...

Full description

Saved in:

Bibliographic Details
Main Authors:	Takanobu Tabuchi (Author), Xiao-Fang Che (Author), Katsuya Hiraishi (Author), Masakazu Adachi (Author), Kei Miyano (Author), Hideki Sumimoto (Author), Takafumi Tabuchi (Author), Keisuke Miyazawa (Author), Akio Tomoda (Author)
Format:	Book
Published:	Elsevier, 2011-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Phenoxazine Derivative Phx-1 Suppresses IgE-Mediated Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells
by: Eisuke Enoki, et al.
Published: (2004)

2-Aminophenoxazine-3-one Prevents Pulmonary Metastasis of Mouse B16 Melanoma Cells in Mice
by: Takayuki Hongo, et al.
Published: (2010)

Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
by: Kyoko Hayashi, et al.
Published: (2010)

Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4' -BNA/LNA with 9-(aminoethoxy)phenoxazine
by: Taiki Matsubayashi, et al.
Published: (2024)

Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine
by: Taiki Matsubayashi, et al.
Published: (2024)

Phenoxazine Derivatives Inactivate Human Cytomegalovirus, Herpes Simplex Virus-1, and Herpes Simplex Virus-2 In Vitro
by: Kyoko Hayashi, et al.
Published: (2008)

Anticancer Effects of Phenoxazine Derivatives Revealed by Inhibition of Cell Growth and Viability, Disregulation of Cell Cycle, and Apoptosis Induction in HTLV-1-Positive Leukemia Cells
by: Naoko Miyano-Kurosaki, et al.
Published: (2009)

Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities
by: Jung-Chun Chu, et al.
Published: (2023)

Anticancer Activity Evaluation of New Thieno[2,3-d]pyrimidin-4(3H)-ones and Thieno[3,2-d]pyrimidin-4(3H)-one Derivatives
by: Olga Shyyka, et al.
Published: (2018)

Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1<i>H</i>)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3<i>H</i>)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents
by: Nahed Nasser Eid El-Sayed, et al.
Published: (2023)

Synthesis of New 3-Substituted Quinazolin-4(3H)-one Compounds Via Linking of Some Five-Membered Ring Heterocyclic Moieties With Quinazolin-4(3H)-one Nucleus
by: Mohammed Al-iraqi, et al.
Published: (2021)

Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of 1,3,4-Thiadiazole Derivatives of 3-Aminopyridin-2(1<i>H</i>)-ones
by: Zarina Shulgau, et al.
Published: (2024)

SYNTHESIS AND ANTIOXIDANT ACTIVITY OF (E)-3-(3-(4-OXO-4H-CHROMEN-3-YL)ACRYLOYL) 2H-CHROMEN-2-ONE DERIVATIVES
by: S. S. Shatokhin, et al.
Published: (2021)

Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins
by: Daniel J. Watson, et al.
Published: (2024)

The Uses of 2-Ethoxy-(4H)-3,1-benzoxazin-4-one in the Synthesis of Some Quinazolinone Derivatives of Antimicrobial Activity
by: Fakhry A. El-Bassiouny, et al.
Published: (2011)

Synthesis of some novel pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives as potential antimicrobial agent
by: Dipen K Sureja, et al.
Published: (2016)

Antidiabetic Potential of Novel 1,3,5-Trisubstituted-2-Thioxoimidazloidin-4-One Analogues: Insights into α-Glucosidase, α-Amylase, and Antioxidant Activities
by: Salma M. Khirallah, et al.
Published: (2022)

Synthesis and antitumor activity of certain 2,3,6-trisubstituted quinazolin-4(3H)-one derivatives
by: Safinaz E. Abbas, et al.
Published: (2013)

Synthesis and evaluation of some new 1,2,4-triazolo(4,3-a)quinoxalin-4-5H-one derivatives as AMPA receptor antagonists
by: Ashraf Bayoumi, et al.
Published: (2012)

Ligand Growing Experiments Suggested 4-amino and 4-ureido pyridazin-3(2<i>H</i>)-one as Novel Scaffold for FABP4 Inhibition
by: Letizia Crocetti, et al.
Published: (2022)

Design, Synthesis and molecular docking study of hybrids of quinazolin-4(3H)-one as anticancer agents
by: Sukanya Nara, et al.

Antibacterial Effects of Quinazolin-4(3<i>H</i>)-One Functionalized-Conjugated Silver Nanoparticles
by: Abdulkader Masri, et al.
Published: (2019)

Quinazolin-4(3H)-one based potential multiple tyrosine kinase inhibitors with excellent cytotoxicity
by: Tebyan O. Mirgany, et al.
Published: (2021)

Synthesis of 3-[2-(1H-imidazol-2-yl)alkyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives
by: O. A. Zavada, et al.
Published: (2018)

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors
by: Adel S. El-Azab, et al.
Published: (2020)

Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors
by: Adel S. El-Azab, et al.
Published: (2020)

Synthesis and antioxidant activity of 3-(2-R-ylidenehydrazinyl)-6-tert-butyl-4H-[1,2,4]triazin-5-ones
by: Yevhenii Novodvorskyi, et al.
Published: (2022)

Facile one-pot synthesis of thiazol-2(3H)-imine derivatives from α-active methylene ketones
by: Dalia E El-Sawah, et al.
Published: (2020)

Creating Antibacterial Properties in Flowable Dental Composites by Incorporation of 3,4-dihydropyrimidin-2(1H)-ones
by: Mehdi Abaszadeh, et al.
Published: (2021)

ANTIMICROBIAL ACTIVITY STUDY OF NEW QUINAZOLIN-4(3H)-ONES AGAINST STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS PNEUMONIAE
by: M. A. Samotrueva, et al.
Published: (2021)

Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues
by: Francesca Nuti, et al.
Published: (2023)

Synthesis and anti-microbial screening of novel schiff bases of 3-amino-2-methyl quinazolin 4-(3H)-one
by: Govindaraj Saravanan, et al.
Published: (2010)

Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives
by: Anita Singh, et al.
Published: (2013)

Antimicrobial evaluation and QSAR studies of 3,6-disubstituted-11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones
by: Satbir Mor, et al.
Published: (2022)

Synthesis and cytotoxic evaluation of some new 3-(2-(2-phenylthiazol-4-yl) ethyl)-quinazolin-4(3H) one derivatives with potential anticancer effects
by: Leila Hosseinzadeh, et al.
Published: (2017)

Design, synthesis and biological Evaluation of novel chromones having 3,4-dihydropyrimidin-2(1H)-one core at C-8 in combination with triazoles: New α-glucosidase inhibitors and anti-bacterial agents
by: Kumara Swamy Taviti, et al.
Published: (2024)

Design, synthesis, and evaluation of 4-(3-(3,5-dimethylisoxazol-4-yl)benzyl)phthalazin-1(2H)-one derivatives: potent BRD4 inhibitors with anti-breast cancer activity
by: Yingpeng Li, et al.
Published: (2023)

Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives
by: Nahed N. E. El-Sayed, et al.
Published: (2019)

Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation
by: Raluca Pele, et al.
Published: (2022)

Synthesis and cytotoxic evaluation of some novel 3-[2-(2-phenyl-thiazol-4-yl)-ethyl] -3H-pyrido [2,3-d]pyrimidin-4-one derivatives
by: Marzieh Rahmani Khajouei, et al.
Published: (2021)