An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells

• Main Authors: Carmen L. Bayly (Author), Xiao-Qing Dai (Author), Cuilan Nian (Author), Paul C. Orban (Author), C. Bruce Verchere (Author), Patrick E. MacDonald (Author), Francis C. Lynn (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to study diabetes pathologies and develop cell replacement therapies. Although current differentiation protocols yield SCβ cells with varying degrees of maturation, these cells still differ from deceased donor hum...