Lack of association between genetic polymorphisms within <it>DUSP12 - </it><it>ATF6 </it>locus and glucose metabolism related traits in a Chinese population
<p>Abstract</p> <p>Background</p> <p>Genome-wide linkage studies in multiple ethnic populations found chromosome 1q21-q25 was the strongest and most replicable linkage signal in the human chromosome. Studies in Pima Indian, Caucasians and African Americans identified se...
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2011-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_fef8d2a9d2fd43c4922e13a672415f6c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xiang Kunsan |e author |
| 700 | 1 | 0 | |a Bao Yuqian |e author |
| 700 | 1 | 0 | |a Wang Jie |e author |
| 700 | 1 | 0 | |a Ma Xiaojing |e author |
| 700 | 1 | 0 | |a Wang Congrong |e author |
| 700 | 1 | 0 | |a Zhang Rong |e author |
| 700 | 1 | 0 | |a Hu Cheng |e author |
| 700 | 1 | 0 | |a Jia Weiping |e author |
| 245 | 0 | 0 | |a Lack of association between genetic polymorphisms within <it>DUSP12 - </it><it>ATF6 </it>locus and glucose metabolism related traits in a Chinese population |
| 260 | |b BMC, |c 2011-01-01T00:00:00Z. | ||
| 500 | |a 10.1186/1471-2350-12-3 | ||
| 500 | |a 1471-2350 | ||
| 520 | |a <p>Abstract</p> <p>Background</p> <p>Genome-wide linkage studies in multiple ethnic populations found chromosome 1q21-q25 was the strongest and most replicable linkage signal in the human chromosome. Studies in Pima Indian, Caucasians and African Americans identified several SNPs in <it>DUSP12 </it>and <it>ATF6</it>, located in chromosome 1q21-q23, were associated with type 2 diabetes.</p> <p>Methods</p> <p>We selected 19 single nucleotide polymorphisms (SNPs) that could tag 98% of the SNPs with minor allele frequencies over 0.1 within <it>DUSP12-ATF6 </it>region. These SNPs were genotyped in a total of 3,700 Chinese Han subjects comprising 1,892 type 2 diabetes patients and 1,808 controls with normal glucose regulation.</p> <p>Results</p> <p>None of the SNPs and haplotypes showed significant association to type 2 diabetes in our samples. No association between the SNPs and quantitative traits was observed either.</p> <p>Conclusions</p> <p>Our data suggests common SNPs within <it>DUSP12</it>-<it>ATF6 </it>locus may not play a major role in glucose metabolism in the Chinese.</p> | ||
| 546 | |a EN | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 690 | |a Genetics | ||
| 690 | |a QH426-470 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n BMC Medical Genetics, Vol 12, Iss 1, p 3 (2011) | |
| 787 | 0 | |n http://www.biomedcentral.com/1471-2350/12/3 | |
| 787 | 0 | |n https://doaj.org/toc/1471-2350 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fef8d2a9d2fd43c4922e13a672415f6c |z Connect to this object online. |