Assessment of severity of cystic fibrosis in children depending on the vitamin D status

• Main Authors: Veronika Dudnyk (Author), Valeriia Demianyshyna (Author)
• Format: Book
• Published: Kazimierz Wielki University, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2391-8306; 10.12775/JEHS.2020.10.09.068
• Keywords: cystic fibrosis; children; vitamin d; severity of the disease.; Education; L; Sports; GV557-1198.995; Medicine; R
• Source: Journal of Education, Health and Sport, Vol 10, Iss 9, Pp 561-568 (2020)

<p><strong>Introduction</strong><strong>.</strong></p><p>Severity of CF depends on speed of lung disease progression which depend on many factors. Patients with CF suffer from vitamin D deficiency that could contribute to decreasing of lung function due to anti-inflammatory and antimicrobial activity. Correction of vitamin D₃ level may be a potentially effective way to keep pulmonary function in such patients.</p><p><strong>Purpose. </strong>Evaluation of severity of CF in children depending on the vitamin D₃ level in blood serum.</p><p><strong>Materials and methods. </strong>84 children suffering from CF have been examined. Level of 25 (ОН) D₃ in blood serum measured with immunosorbent assay. Patients were performed spirometry and the bacteriograms of sputum coughed up by children were analyzed.</p><p><strong>Results. </strong><strong> </strong>Measurement of serum vitamin D₃ among children with cystic fibrosis showed that 58,3% of subjects had insufficiency. Children who suffered from severe CF had significant lower serum 25 (OH) D₃ concentrations. It was shown that children with insufficient level of 25 (OH) D₃ had higher risk of FEV₁ rate decreasing less than 64 %, and significant association with <em>Ps. </em><em>a</em><em>eruginosa</em><em>-</em>positive<em> </em>culture was detected. Subjects with sufficient 25 (OH) D₃ had strong association with higher rates of FEV₁ and risk of <em>Ps. </em><em>a</em><em>eruginosa</em><em>-</em>positive<em> </em>culture was also decreased.</p><p><strong>Conclusions</strong><strong>. </strong>Vitamin D insufficiency is common among children with cystic fibrosis. It was found that there is a relationship between the content of 25 (OH) D₃ and the severity of the disease. Children with low levels of 25 (OH) D₃ are associated with lower FEV1 rates and have a higher risk of positive culture of <em>Ps. aeruginosa.</em></p><p> </p>