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Case Report: Response to Almonertinib in a Patient With Metastatic NSCLC Resistant to Osimertinib due to Acquired EGFR L718Q Mutation

Osimertinib shows strong clinical activity in first- and second-line treatment of nonsmall-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, especially EGFR T790M. However, when patients develop resistance, there is currently no definite postosimertinib treatm...

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Bibliographic Details
Main Authors: Gang Shen (Author), Lei Shi (Author), Xin Tian (Author), Depei Huang (Author), Hao Chen (Author), Chan Gao (Author), Xudong Shen (Author), Hushan Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
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Summary:Osimertinib shows strong clinical activity in first- and second-line treatment of nonsmall-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, especially EGFR T790M. However, when patients develop resistance, there is currently no definite postosimertinib treatment option. Herein, we report a patient with metastatic NSCLC who benefited from almonertinib after developing resistance to osimertinib.
Item Description:1663-9812
10.3389/fphar.2021.731895

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