Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL/6 mice

• Main Authors: Kazuki Matsui (Author), Maho Tsubota (Author), Saaya Fukushi (Author), Nene Koike (Author), Hiroshi Masuda (Author), Yoshihito Kasanami (Author), Takaya Miyazaki (Author), Fumiko Sekiguchi (Author), Tsuyako Ohkubo (Author), Shigeru Yoshida (Author), Yutaro Mukai (Author), Akira Oita (Author), Mitsutaka Takada (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We tested whether genetic deletion of Cav3.2 T-type Ca2+ channels abolishes hydrogen sulfide (H2S)-mediated pain signals in mice. In Cav3.2-expressing HEK293 cells, Na2S, an H2S donor, at 100 μM clearly increased Ba2+ currents, as assessed by whole-cell patch-clamp recordings. In wild-type C57BL/6 m...