Letter to the editor concerning the article 'Association between rotavirus vaccination and risk of intussusception among neonates and infants: a systematic review and meta-analysis' (JAMA Netw Open. 2019;2(10):e1912458)

A recent meta-analysis investigating the association between intussusception (IS) and rotavirus (RV) vaccination demonstrated an absence of risk up to 2 years after vaccination. Meta-analyses including only randomized clinical trials are inadequate to identify a potential increased risk of rare adve...

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Main Authors: Bernd Benninghoff (Author), Priya Pereira (Author), Corinne Willame (Author)
Format: Book
Published: Taylor & Francis Group, 2020-10-01T00:00:00Z.
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100 1 0 |a Bernd Benninghoff  |e author 
700 1 0 |a Priya Pereira  |e author 
700 1 0 |a Corinne Willame  |e author 
245 0 0 |a Letter to the editor concerning the article 'Association between rotavirus vaccination and risk of intussusception among neonates and infants: a systematic review and meta-analysis' (JAMA Netw Open. 2019;2(10):e1912458) 
260 |b Taylor & Francis Group,   |c 2020-10-01T00:00:00Z. 
500 |a 2164-5515 
500 |a 2164-554X 
500 |a 10.1080/21645515.2020.1730119 
520 |a A recent meta-analysis investigating the association between intussusception (IS) and rotavirus (RV) vaccination demonstrated an absence of risk up to 2 years after vaccination. Meta-analyses including only randomized clinical trials are inadequate to identify a potential increased risk of rare adverse events such as IS. The study conducted failed to discuss relevant limitations. Additionally, the safety profiles of newer RV vaccines, evaluated in clinical studies with limited sample size, were considered comparable with that of the well-established and widely used RV vaccines, RotaTeq and Rotarix. We, therefore, re-emphasize that extensive and updated evidence from post-marketing surveillance indicates a slight increased risk of IS, mostly within 7 days of RV vaccination, with a benefit/risk profile assessment in favor of RV vaccination. 
546 |a EN 
690 |a rotavirus vaccines 
690 |a intussusception 
690 |a safety 
690 |a Immunologic diseases. Allergy 
690 |a RC581-607 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Human Vaccines & Immunotherapeutics, Vol 16, Iss 10, Pp 2502-2503 (2020) 
787 0 |n http://dx.doi.org/10.1080/21645515.2020.1730119 
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