Spontaneous breathing approach in mild congenital diaphragmatic hernia: A resuscitation algorithm

BackgroundInfants with a congenital diaphragmatic hernia (CDH) and expected mild pulmonary hypoplasia have an estimated survival rate of 90%. Current guidelines for delivery room management do not consider the individual patient's disease severity, but an individualized approach with spontaneou...

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Main Authors: Emily J. J. Horn-Oudshoorn (Author), Ronny Knol (Author), Suzan C. M. Cochius-den Otter (Author), Arjan B. te Pas (Author), Stuart B. Hooper (Author), Calum T. Roberts (Author), Neysan Rafat (Author), Thomas Schaible (Author), Willem P. de Boode (Author), Robin van der Lee (Author), Anne Debeer (Author), Florian Kipfmueller (Author), Charles C. Roehr (Author), Irwin K. M. Reiss (Author), Philip L. J. DeKoninck (Author)
Format: Book
Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Emily J. J. Horn-Oudshoorn  |e author 
700 1 0 |a Ronny Knol  |e author 
700 1 0 |a Suzan C. M. Cochius-den Otter  |e author 
700 1 0 |a Arjan B. te Pas  |e author 
700 1 0 |a Stuart B. Hooper  |e author 
700 1 0 |a Calum T. Roberts  |e author 
700 1 0 |a Calum T. Roberts  |e author 
700 1 0 |a Neysan Rafat  |e author 
700 1 0 |a Thomas Schaible  |e author 
700 1 0 |a Willem P. de Boode  |e author 
700 1 0 |a Robin van der Lee  |e author 
700 1 0 |a Anne Debeer  |e author 
700 1 0 |a Florian Kipfmueller  |e author 
700 1 0 |a Charles C. Roehr  |e author 
700 1 0 |a Charles C. Roehr  |e author 
700 1 0 |a Charles C. Roehr  |e author 
700 1 0 |a Irwin K. M. Reiss  |e author 
700 1 0 |a Philip L. J. DeKoninck  |e author 
700 1 0 |a Philip L. J. DeKoninck  |e author 
245 0 0 |a Spontaneous breathing approach in mild congenital diaphragmatic hernia: A resuscitation algorithm 
260 |b Frontiers Media S.A.,   |c 2022-07-01T00:00:00Z. 
500 |a 2296-2360 
500 |a 10.3389/fped.2022.945090 
520 |a BackgroundInfants with a congenital diaphragmatic hernia (CDH) and expected mild pulmonary hypoplasia have an estimated survival rate of 90%. Current guidelines for delivery room management do not consider the individual patient's disease severity, but an individualized approach with spontaneous breathing instead of routine mechanical ventilation could be beneficial for the mildest cases. We developed a resuscitation algorithm for this individualized approach serving two purposes: improving the success rate by structuring the approach and providing a guideline for other centers.MethodsAn initial algorithm was discussed with all local stakeholders. Afterwards, the resulting algorithm was refined using input from international experts.ResultsEligible CDH infants: left-sided defect, observed to expected lung-to-head ratio ≥50%, gestational age at birth ≥37.0 weeks, and no major associated structural or genetic abnormalities. To facilitate fetal-to-neonatal transition, we propose to start stabilization with non-invasive respiratory support and to adjust this individually.ConclusionsInfants with mild CDH might benefit from an individualized approach for neonatal resuscitation. Herein, we present an algorithm that could serve as guidance for centers implementing this. 
546 |a EN 
690 |a congenital diaphragmatic hernia 
690 |a intubation 
690 |a spontaneous breathing approach 
690 |a neonatal resuscitation 
690 |a birth 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pediatrics, Vol 10 (2022) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fped.2022.945090/full 
787 0 |n https://doaj.org/toc/2296-2360 
856 4 1 |u https://doaj.org/article/ff9897b6e87c48cdb10f6069cb47e85c  |z Connect to this object online.