The role of interaction between keratinocytes and type 2 inflammation in the pathogenesis of atopic dermatitis

• Main Authors: Ruiwen ZHANG (Author), Xiaobao HUANG (Author), Fang WANG (Author)
• Format: Book
• Published: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1674-8468; 10.3969/j.issn.1674-8468.2024.01.009
• Keywords: atopic dermatitis; keratinocyte; type 2 inflammation; biologics; small molecule drugs; Dermatology; RL1-803
• Source: Pifu-xingbing zhenliaoxue zazhi, Vol 31, Iss 1, Pp 48-55 (2024)

Patients with atopic dermatitis (AD) have skin barrier dysfunction, which is closely related to keratinocyte (KC) abnormalities. Upon stimulation by external factors, KCs release a large number of inflammatory mediators, thereby activating type 2 inflammation, which, in turn, exacerbates skin barrier dysfunction. Thus, the interaction between KCs and type 2 inflammation is a key factor in the pathogenesis of AD, and exacerbation of inflammation and pruritus. At present, the innovative medications, such as biologics and small molecule drugs, have been shown anti-inflammatory effects in AD. Studies also demonstrate their role in skin barrier repair. Therefore, research on the interaction between KCs and type 2 inflammation will help understand the pathogenesis of AD and provide evidence to optimize treatment strategies for AD.