Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma

• المؤلفون الرئيسيون: Qian Liu (مؤلف), Lijuan Hua (مؤلف), Chen Bao (مؤلف), Luxia Kong (مؤلف), Jiannan Hu (مؤلف), Chao Liu (مؤلف), Ziling Li (مؤلف), Shuyun Xu (مؤلف), Xiansheng Liu (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background: Regulation or restoration of therapeutic sensitivity to glucocorticoids is important in patients with steroid-resistant asthma. Spleen tyrosine kinase (Syk) is activated at high levels in asthma patients and mouse models, and small-molecule Syk inhibitors such as R406 show potent anti-in...