Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats
Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats....
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Belgorod National Research University,
2019-09-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_ffdfd14eb10b40f99fe84c0319d0b0f0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Natalia I. Nesterova |e author |
| 700 | 1 | 0 | |a Olesya V. Shcheblykina |e author |
| 700 | 1 | 0 | |a Pavel D. Kolesnichenko |e author |
| 700 | 1 | 0 | |a Arkady V. Nesterov |e author |
| 700 | 1 | 0 | |a Dmitry V. Shcheblykin |e author |
| 700 | 1 | 0 | |a Dmitry Yakovlev |e author |
| 245 | 0 | 0 | |a Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats |
| 260 | |b Belgorod National Research University, |c 2019-09-01T00:00:00Z. | ||
| 500 | |a 10.3897/rrpharmacology.5.36988 | ||
| 500 | |a 2658-381X | ||
| 520 | |a Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model. Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% - in the Mexidol- and Ethoxidol-treated groups, and 20% - in LKhT 3-17-treated group). Within the first day after the surgery, all rats with stroke had severe neurological disorders. However, by the 3rd day, the Ethoxidol- and LKhT 3-17-treated rats had a lower neurological deficit. By Day 14, all groups of animals treated with the test substances had a lower severity of post-stroke disorders than those in the control group, which was evident as a 1.5-time lower McGraw Stroke Index score. LKhT 3-17 substance showed the most pronounced neuroprotective effect. Conclusions: The studied derivatives of taurine and 3-hydroxypyridine have a neuroprotective effect, which is manifested in the lower severity of neurological disorders,a more rapid reduction in the signs of neurodegeneration and accelerated hemorrhage processes. | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Research Results in Pharmacology, Vol 5, Iss 3, Pp 87-94 (2019) | |
| 787 | 0 | |n https://rrpharmacology.pensoft.net/article/36988/download/pdf/ | |
| 787 | 0 | |n https://rrpharmacology.pensoft.net/article/36988/download/xml/ | |
| 787 | 0 | |n https://rrpharmacology.pensoft.net/article/36988/ | |
| 787 | 0 | |n https://doaj.org/toc/2658-381X | |
| 856 | 4 | 1 | |u https://doaj.org/article/ffdfd14eb10b40f99fe84c0319d0b0f0 |z Connect to this object online. |