Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma

• Main Authors: Naglaa Mohamed Ahmed (Author), Mahmoud Youns (Author), Moustafa Khames Soltan (Author), Ahmed Mohammed Said (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Fag: article
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New anticancer agents are highly needed to overcome cancer cell resistance. A novel series of pyrimidine pyrazoline-anthracene derivatives (PPADs) (4a-t) were designed and synthesised. The anti-liver cancer activity of all compounds was screened in vitro against two hepatocellular carcinoma (HCC) ce...