Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair

• Main Authors: Shih‐Heng Chen (Author), Hsin‐Wen Wang (Author), Pei‐Ching Yang (Author), Shih‐Shien Chen (Author), Chia‐Hsin Ho (Author), Ying‐Chi Kao (Author), Shao‐Wen Liu (Author), Han Chiu (Author), Yu‐Jie Lin (Author), Er‐Yuan Chuang (Author), Jen‐Huang Huang (Author), Huang‐Kai Kao (Author), Chieh‐Cheng Huang (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The prognosis for postinjury peripheral nerve regeneration remains suboptimal. Although transplantation of exogenous Schwann cells (SCs) has been considered a promising treatment to promote nerve repair, this strategy has been hampered in practice by the limited availability of SC sources a...