Molecular imaging in Parkinson's disease
The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychologica...
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Format: | Electronic Book Chapter |
Language: | English |
Published: |
Firenze
Firenze University Press
2011
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Series: | Premio Tesi di Dottorato
18 |
Subjects: | |
Online Access: | OAPEN Library: download the publication OAPEN Library: description of the publication |
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100 | 1 | |a Polito, Cristina |4 auth | |
245 | 1 | 0 | |a Molecular imaging in Parkinson's disease |
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490 | 1 | |a Premio Tesi di Dottorato |v 18 | |
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520 | |a The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by-nd/3.0/ |2 cc |4 https://creativecommons.org/licenses/by-nd/3.0/ | ||
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650 | 7 | |a Medicine |2 bicssc | |
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856 | 4 | 0 | |a www.oapen.org |u https://library.oapen.org/handle/20.500.12657/54963 |7 0 |z OAPEN Library: description of the publication |