A study on cholinergic signal transduction pathways involved in short term and long term memory formation in the rat hippocampus Molecular and cellular alterations underlying memory impairments in animal models of neurodegeneration
Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the patho...
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| Autor principal: | |
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| Formato: | Recurso Electrónico Capítulo de Livro |
| Idioma: | inglês |
| Publicado em: |
Florence
Firenze University Press
2015
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| Colecção: | Premio Tesi di Dottorato
46 |
| Assuntos: | |
| Acesso em linha: | OAPEN Library: download the publication OAPEN Library: description of the publication |
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| Resumo: | Neurodegenerative processes alter neuronal and glial physiology and cause cognitive and mnemonic impairments. Aim of this PhD thesis is to investigate the involvement of the cholinergic system and the role of mTOR pathway in the mechanisms of memory encoding in the hippocampus and to study the pathophysiological processes at the base of the cognitive impairments in different experimental models of neurodegeneration: in particular normal brain aging, neuroinfiammation and chronic cerebral hypoperfusion. These mechanisms are studied focusing on the morpho-functional alterations in the neuron-astrocytemicroglia triad. |
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| Descrição Física: | 1 electronic resource (136 p.) |
| ISBN: | 978-88-6655-941-2 9788866559412 9788866559405 9788892733114 |
| Acesso: | Open Access |