Cerebral Small Vessel Disease and Cerebral Amyloid Angiopathy Neuroimaging markers, cognitive features and rehabilitative issues

• मुख्य लेखक: Valenti, Raffaella (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Florence Firenze University Press 2018
• श्रृंखला: Premio Tesi di Dottorato 67
• विषय: Cardiovascular medicine
• ऑनलाइन पहुंच: OAPEN Library: download the publication; OAPEN Library: description of the publication

Sporadic cerebral small vessel disease (SVD) is considered to be among the most commonly known neuropathological processes in the brain, hosting a crucial role in stroke, cognitive impairment, and functional loss in elderly subjects. We investigated clinical (neuroimaging and cognitive) biomarkers in the SVD, through a series of analyses from our five studies. Sporadic cerebral SVD is a complex 'micro-world' to be globally considered. All the relevant lesion types and SVD neuroimaging burden should be taken into account. The cumulative effects of microangiopathy burden in the brain of patients affected by SVD are crucial. Cognitive rehabilitation could represent a promising approach to prevent vascular dementia or to improve cognitive performances in patients with cerebral SVD. Longitudinal studies may provide more robust information about the progression and prognostic significance of our findings.