Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury

• Tác giả chính: Bale, Gemma (auth)
• Tác giả khác: Taylor, Nathan (auth), Mitra, Subhabrata (auth), Sudakou, Aleh (auth), Roever, Isabel de (auth), Meek, Judith (auth), Robertson, Nicola (auth), Tachtsidis, Ilias (auth)
• Định dạng: Điện tử Chương của sách
• Ngôn ngữ: Tiếng Anh
• Được phát hành: Springer Nature 2020
• Những chủ đề: Neonatal medicine; Near-infrared spectroscopy; Cerebral blood flow; Neonatal brain injury; Hypoxic-ischaemic encephalopathy; Clinical
• Truy cập trực tuyến: OAPEN Library: download the publication; OAPEN Library: description of the publication

Tóm tắt

Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin - deoxygenated-haemoglobin) combined with arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes. The method is based on Fick's principle and uses HbD as a tracer; when a sudden change in SaO2 occurs, the change in HbD represents a change in tracer concentration, and thus it is possible to estimate CBF. CBF was successfully calculated with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g−1 min−1 with a range of 4 ml 100 g−1 min−1 to 60 ml 100 g−1 min−1. For infants with severe HIE (as determined by magnetic resonance spectroscopy) CBF was significantly lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth.

Mô tả vật lý

1 electronic resource (7 p.)

số ISBN

978-3-030-34461-0_1
9783030344597

Truy cập

Open Access