Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance
In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configu...
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| Format: | Electronic Book Chapter |
| Language: | English |
| Published: |
CABI
2022
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| Online Access: | OAPEN Library: download the publication OAPEN Library: description of the publication |
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| Summary: | In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configurations based on the use of sex-specific components and their effect on introduction thresholds. We conclude with a discussion on the cycle of information between mathematical models and experimental data along with a range of areas for future modelling that will be important in providing information on the anticipated effects of these systems when released into target populations. |
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| Physical Description: | 1 electronic resource (20 p.) |
| ISBN: | 9781800621176.0012 9781800621152 9781800621176 |
| Access: | Open Access |