Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance

In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configu...

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Κύριος συγγραφέας: Edgington, Matthew P. (auth)
Άλλοι συγγραφείς: Alphey, Luke (auth)
Μορφή: Ηλεκτρονική πηγή Κεφάλαιο βιβλίου
Γλώσσα:Αγγλικά
Έκδοση: CABI 2022
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Περιγραφή
Περίληψη:In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configurations based on the use of sex-specific components and their effect on introduction thresholds. We conclude with a discussion on the cycle of information between mathematical models and experimental data along with a range of areas for future modelling that will be important in providing information on the anticipated effects of these systems when released into target populations.
Φυσική περιγραφή:1 electronic resource (20 p.)
ISBN:9781800621176.0012
9781800621152
9781800621176
Πρόσβαση:Open Access