Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance
In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configu...
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| Language: | English |
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2022
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| 100 | 1 | |a Edgington, Matthew P. |4 auth | |
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| 245 | 1 | 0 | |a Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance |
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| 520 | |a In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configurations based on the use of sex-specific components and their effect on introduction thresholds. We conclude with a discussion on the cycle of information between mathematical models and experimental data along with a range of areas for future modelling that will be important in providing information on the anticipated effects of these systems when released into target populations. | ||
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