Dental aspects of children with Down syndrome

• Main Authors: Ambarkova Vesna (Author), Ana Sotirovska Ivkovska (Author), Natasa Stavreva (Author)
• Format: Book
• Published: Journal of Dental Problems and Solutions - Peertechz Publications, 2017-08-09.
• Subjects: Case Report
• Online Access: Connect to this object online.

<p>Down syndrome (trisomy 21) is the most common autosomal chromosome aberration in human. The incidence of the syndrome varies in 1:700 and 1:1000 live births according to various studies, with 20% of cases. In aborted material proportion is even higher, with 60% of cases. While 20% of cases with Down syndrome are stillborn. <br></p><p>In these patients, there is a strong predisposition to cardiovascular disease, seizures [1], leukemia[2,3], infections with hepatitis B virus (especially within institutionalized men)[4], upper respiratory tract infections [5], Alzheimer's disease[6], obesity [7], thyroid diseases [8], cardiac anomalies [9], and obstructive sleep apnea [10,11]. Disruption of the proteostasis network and accumulation of misfolded proteins occur as a result of an abnormality in the number of hromosome 21 [12]. Errors in protein homeostasis could contribute to the observed pathology and decreased cell viability in children with Down syndrome [13].</p>