Fresh frozen plasma as a source of plasminogen for ligneous conjunctivitis: Case report and a review of the literature

• Main Authors: Benjamin J Park (Author), David Camoriano (Author), Mark C Vital (Author), Patricia Chévez-Barrios (Author), John D Goosey (Author), Marcel Belloso (Author)
• Format: Book
• Published: Journal of Clinical Research and Ophthalmology - Peertechz Publications, 2021-07-19.
• Subjects: Case Report
• Online Access: Connect to this object online.

<p>Purpose: To describe management of a patient with ligneous conjunctivitis secondary to plasminogen deficiency and review the literature on treatment with plasminogen.</p><p>Design: Interventional case report.</p><p>Methods: A 6-year-old Caucasian girl developed ligneous conjunctivitis recalcitrant to debridement and treatment with topical cyclosporin A and steroids. The literature was reviewed regarding treatment of ligneous conjunctivitis with plasminogen.</p><p>Results: The patient was treated with plasminogen containing drops derived from her father's fresh frozen plasma. The ligneous conjunctivitis resolved, and the patient was managed on these drops for the following 8 years, initiating treatment for flares and tapering according to clinical response.</p><p>Conclusions: Plasminogen drops concentrated from fresh frozen plasma are a safe and effective option for long-term treatment of ligneous conjunctivitis.</p>