Evaluation of the efficacy of the utilization of the imipramine for patients with allergic rhinitis

• Main Authors: Diaa El Din El Hennawi (Author), Mohamed Rifaat Ahmed (Author), Yasser T Madian (Author), Mohammed T El-Tabbakh (Author), Ibrahim Hassan Ibrahim (Author)
• Format: Book
• Published: Archives of Otolaryngology and Rhinology - Peertechz Publications, 2017-07-26.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p><strong>Background:</strong> allergic rhinitis is an infl ammatory process of the upper respiratory tract with a continuous symptom that last for hour or more with symptom affect patient's work and quality of life. </p><p><strong>Methodology:</strong> a randomized controlled trial in which we enrolled 284 patients with allergic rhinitis for periods longer than 4 days/week and for more than 4 consecutive weeks divided into two groups. Group A (n=142) received Imipramine 75 mg/day for 90 days .Group B (n=142), the control group, received desloratadine 5 mg / day for 90 days.</p><p><strong>Results:</strong> The mean visual analogue score nasal symptoms intensity (sneezing, Nasal obstruction, watery rhinorrhea and itchy nose) showed a statistically signifi cantly improvement in group A (treated with Imipramine) compared with group B (treated with desloratadine) after the same treatment period.</p><p><strong>Conclusion:</strong> Imipramine could be used in treatment patients with allergic rhinitis as it is effective as an antihistaminic besides its main action in reliving psychosocial stresses.</p>